Mechanism:

  • T = Decreased transcription of the catalase gene [R]

  • C = Increased transcription of the catalase gene [R]

The Minor "T" allele is associated with:

  • Decreased acoustic neuroma (noncancerous tumor in nerve leading from ear to brain) risk in non-Hispanic whites [R]

  • Increased chance of cardiac damage after exposure to anthracyclines [R]

  • An increased risk of type-2 diabetes [R]

  • Increased risk of myocardial infarction following cardiac surgery [R]

  • Increased risk of death from rectal cancer following radiotherapy [R]

  • Increased visual acuity [R]

The Major "C" allele is associated with:

  • Increased acoustic neuroma (noncancerous tumor in nerve leading from ear to brain) risk in non-Hispanic whites [R]

  • A decreased risk of type-2 diabetes [R]

  • Decreased risk of myocardial infarction following cardiac surgery [R]

  • Decreaseed risk of death from rectal cancer following radiotherapy [R]

  • Decreased visual acuity [R]

This SNP is associated with (unknown  which alleles):

  • Decreased susceptibility to the effects of particulate air pollution [R]

  • Increased risk of breast cancer [R]

  • Increase susceptibility to malaria infection in the Indian population [R]

Increase clinical expression of Wilson’s Disease [R]

rs1001179

Parent Gene: CAT

Importance: 4
Less common allele: T = 13%
More common allele: C = 87%
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