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VEGF genepack

Author: jamiegatesmassage
Genes in this gene pack: VEGFA

VEGF gene

VEGF inhibitor health effect

VEGF protein, zebrafish chemical

64Cu-DOTA-VEGF(DEE) chemical

QK VEGF mimetic peptide chemical

Synonyms: Ac-KLTWQELYQLKYKGI-NH2

VEGF-A-activated receptor activity molecular function

VEGF-B-activated receptor activity molecular function

VEGF-activated neuropilin signaling pathway biological process

VEGF-F, Daboia russelli siamensis chemical

VEGF-activated neuropilin signaling pathway involved in axon guidance biological process

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway biological process

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway biological process

rs25648 snp

Genes: VEGFA
SNP description: [PMID 19692168] Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes


[PMID 16645995] Vascular endothelial growth factor gene haplotypes in Kawasaki disease.

[PMID 19308252] Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation.

[PMID 19372140] EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis.

[PMID 19587357] A systematic meta-analysis of genetic association studies for diabetic retinopathy.

[PMID 19755511] The role of vascular endothelial growth factor SNPs as predictive and prognostic markers ...

rs3025020 snp

Genes: VEGFA
SNP description:

The T (minor) allele is associated with:

  • TT= higher VEGF protein levels which can promote the growth of cancer and other vascular diseases (R1,R2,R3).

The C (major) allele is associated with:

  • CC= Increased risk of vasoocclusive crisis in sickle cell disease (R).

rs1485766 snp

Genes: VEGFC
SNP description:

Mechanism:

  • TT= Normal levels of Vascular Endothelial Growth Factor C (VEGF-C) in the body.
  • T (major) allele= Normal levels of VEGF-C in the body.
  • G (minor) allele= Increased levels of VEGF-C in the body [R].
  • VEGF-C is an important promoter of cell growth, survival, and migration [R]. Because it is a growth factor, VEGF-C has also been known to promote the growth of some cancers [R].

The G (minor) allele is associated with:

  • Urothelial Cell Carcinoma (UCC) [R]. This affects the urinary system (Kidney, Bladder) [R].
  • Hepatocellular Carcinoma (HCC) [R].
  • Oral cancer [R]...

rs7664413 snp

Genes: VEGFC
SNP description:

Mechanism:

  • CC= Normal levels of Vascular Endothelial Growth Factor C (VEGF-C) in the body.
  • C (major) allele= Normal levels of VEGF-C in the body.
  • T (minor) allele= Higher levels of VEGF-C in the body [R].
  • VEGF-C is an important promoter of cell growth, survival, and migration [R]. Because it is a growth factor, VEGF-C has also been known to promote the growth of some cancers [R].

The T (minor) allele is associated with:

  • Hepatocellular carcinoma (HCC) [R].
  • Increased severity of HCC due to increased tumor size [R[R].
  • Urothelial cell carcinoma (UCC) [R]. This ...

rs3025000 snp

Genes: VEGFA
SNP description:

Mechanism:

This SNP is located in the intron region of the VEGF-A, meaning it can lead to the protein being bigger or smaller than it originally was. This can affect protein function (R).

The T (minor) allele is associated with:

  • Increased BMI (R).
  • Increased Risk of Diabetes and higher proinsulin (R).
  • Increased risk of Crohns Disease (R).
  • Increased risk of Ulcerative Colitis (R).
  • Increased risk of spontaneous Miscarriage (R).
  • Increased risk of Sarcoidosis (R).
  • Decreased Lower lung function (R).
  • Increased chance of seizures coming back (R).
  • Increased Flucloxacillin...

rs3025035 snp

Genes: VEGFA
SNP description:

Mechanism:

  • Codes for vascular endothelial growth factor A, which is associated with better production of new blood vessels and increased nutrient flow, promoting cell growth/development, and decreasing cell death [R].

The T (minor) allele is associated with:

  • Shortened survival for liver-transplant patients [R].

The C (major) allele is associated with:

  • Increased risk of Liver cancer [R].
  • Increased Relapses of breast cancer [R].

This SNP is associated with (unknown which alleles):

  • SNP Rs3025021 [R].
  • Bladder cancer [R].
  • Lupus in Asian populations [R...

rs3025039 snp

Genes: VEGFA
SNP description:

Mechanism:

  • TT:higher VEGF plasma production [R]
  • TC:average VEGF secretion [R]
  • CC:lower VEGF production (loss of a potential binding site for AP-4 [R])

The T (minor) allele is associated with:

  • Increased vascular permeability [R]
  • Lowered risk for macular degeneration (AMD)[R]
  • Increased risk for non-alcoholic fat liver disease (NAFLD) [R]
  • Bisphosphonate-related osteonecrosis of the jaw (Korean population) [R]

The C (major) allele is associated with:

  • Increased susceptibility to gastric cancer [R]
  • Increased susceptibility to Diabetic Retinopathy(in Asian p...

rs833061 snp

Genes: VEGFA
SNP description:

[PMID 19761764] Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population


[PMID 19594543] Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer

[PMID 19875757] Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy



[PMID 20847577] Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Neovascular Age-Related Macular Degeneration in a Ch...

rs833068 snp

Genes: VEGFA
SNP description:

Mechanism:

  • G= associated with an increase in production of Vascular Endothelial Growth Factor (VEGF).[R], [R].

The "A" (minor) allele is associated with:

  • AA= Increased risk for vaso-occlusive crisis in individuals with Sickle Cell Disease [R].

  • Increased risk for cervical cancer [R], as part of the CTGCCAG haplotype regarding SNP’s rs699947/ rs833061/ rs1570360/  rs2010963/ rs25648/ rs833068/ rs833070, based on a study of Tunisian women.

  • AA with Ovarian cancer showed significantly lower survival, in one study of an Australi...

rs833069 snp

Genes: VEGFA
SNP description:

Mechanism:

The C allele= an increase in VEGFA levels and expression [R].

The C (minor) allele is associated with:

  • Increased risk of AMD (age related macular degeneration) [R].
  • a 6.25-fold increased risk of Polypoidal Choroidal Vasculopathy (CC vs TT) while the CT group had a 1.82-fold increased risk (Koreans). [R]
  • Lower likelihood of Diabetic retinopathy (DR) ,which accounts for 8% of legal blindness in the United States [R].
  • An increased survival rate in children after surgery for Congenital Heart Disease (CHD) [R]

  • An increased overall survival rate in ch...

rs2146323 snp

Genes: VEGFA
SNP description:

The A (minor) Allele is associated with:

  • A better response to Inhaled Corticosteroid Therapy in Asthmatics [R].
  • Worse response to leukotriene receptor antagonist (LTRA) montelukast (a non steroidal therapy that acts as an anti inflammatory agent for the bronchi) in Asthmatics [R].
  • A better response to Photodynamic Therapy (PDT) in macular degeneration subjects [R].
  • Increased risk of Diabetic Retinopathy [R][R][R].

This SNP is associated with (unknown which allele):

  • Hippocampal structure, which controls memory and emotions [R].