rs1805502 is a SNP of the GRIN2B gene. It is significantly associated with mental disorders.
There was a significant association between the ''G'' allele and treatment-resistant depression (TRD) with an excess of this allele in the TRD group, compared to non-TRD group (OR = 1.55, corrected P = 0.008) [R].
The minor allele ''G'' was associated with a significant lower reasoning ability in schizophrenia. In the postmortem brain, the ''G'' allele was associated with reduced expression of ...
''C'' allele is associated with a lower risk of sudden cardiac death (SCD). Among GG homozygotes, hypertension was a major risk factor for sudden cardiac death (SCD) due to coronary heart disease (CHD) (OR= 3.75, P < 0.001) and hypertension was also associated with larger coronary atherosclerotic plaque areas (P = 0.002) and the occurrence of complicated plaques (OR 8.38, P < 0.001) [R].
''G'' allele was associated with an increased risk of ischemic stroke (IS) in patients with large artery atherosclerosis (LAA) (OR = 1.583, P = 0.02)&...
The ''T'' allele was positively associated with treatment response (p = 0.0190; OR 1.537) in patients with chronic hepatitis C [R].
The ''G'' allele was associated with an increased risk of ischemic stroke (IS) with an odds ratios (OR) of 1.358 (P = 0.002) [R].
The allele ''T'' confers a 1.47-fold increased risk of developing tuberculosis (TB) (P = 0.0001, OR = 1.47) [R].
The individuals carrying TG/GG genotype of G/T polymorphism were associated with an increased asthma risk in reces...
The Minor allele “T” is associated with:
Lower risk of alcohol dependence and major depression (in haplotype with rs182402 and rs324650) [R].
Higher BMI in males and greater risk of obesity [R].
The Major allele “C” is associated with:
Earlier age of onset for alcohol dependence [R].
Unknown SNP association:
Based on a study of 790 individuals from 245 nuclear families (220 families were European Caucasian; 300 of the probands had a diagosis of schizophrenia), the rs2070106(G) allele was overtransmitted to affected offspring.[PMID 18496213]
This actually conflicts with a previous report [PMID 16389193] in which the rs2070106(A) allele was identified (also in Caucasians) in a combined gene association/expression study as associated with schizophrenia.
This is either a case of the "flip-flop" phenomenon [PMID 17273975] in which multilocus effects and variation in interlocus correlations reverse ...
The TT genotype was strongly and significantly associated with Ruminative Response Scale (RRS) scores (a predictive of relapse and recurrence of depression) [R].
rs2230912, also known as Q460R, is a SNP in the purinergic receptor P2X, ligand-gated ion channel, 7 P2RX7 gene.
This SNP has been reported to be associated with increased risk for bipolar disorder in one study [PMID 18268501], but the association was not replicated in a large UK case-control sample (bipolar I disorder N = 687, unipolar recurrent major depression N = 1,036, controls N = 1,204)[PMID 19160446].
The G allele is the putative risk allele.