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unipolar depression disease

Definition: A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts.

Help for depression forum

Hi all. I'm pretty new to this site. It seems like there is a lot of info but I can't really figure out how to weed through it. I would say...

Depression genepack

Author: m.gundinger
Genes in this gene pack: BDNF, FKBP5, HTR2A, SLC6A4, TPH2

Depression genepack

Author: churd25
Genes in this gene pack: AKT1, BDNF, CHRM2, CNR1, DIO1, DRD2, GSK3B, HTR1A, HTR2A, HTR2C, IRF5, MAOA, OXTR, TPH2

Anxiety, extreme anger, major depression and OCD forum


I just signed up and just wanted to say I am absolutely amazed at the amount of info on your website Joe! Nearly every time I search the net usi...

Methylfolate and Resistant Depression Via Emily Deans M.D. (Evolutionary Psychiatry) forum

I am sharing this article, very interesting read. Including citations.

Link here:

Depression, Postpartum trait

Major Depression trait

long term synaptic depression biological process

regulation of long term synaptic depression biological process

negative regulation of long term synaptic depression biological process

positive regulation of long term synaptic depression biological process

rs6277 snp

Genes: DRD2
SNP description:


  • Decreased dopamine signaling (AA) [R].
  • Lower DRD2 (A) [R].
  • Low striatal DRD2 availability (GG) [R]
  • High extrastriatal DRD2  (GG)[R]

The Minor "A" allele is associated with:

  • Needing higher dose of methadone [R].
  • A longer time to reach the maximum methadone dose (P=0.025) [R].
  • Better response to treatment with methadone than patients with GG genotype (AA) (AG) [R]
  • Tend to be better NoGo learners (AA) [R]. NoGo is a game measuring the ability to hold off on the action of button pushing [R]. Higher dopamine in the basal gangl...

rs6354 snp

Genes: SLC6A4
SNP description:

rs6354 was significantly associated with anxiety and/or depression and neuroticism (OR = 1.55) [R]. 

Subjects with one copy of the minor allele ''G'' had higher Beck Depression Inventory scores  (P< or =0.008) and IL-6 levels (P<0.008) [R].



rs636832 snp

Genes: AGO1
SNP description:

[PMID 20721975] Association of a common AGO1 variant with lung cancer risk: A two-stage case-control study

[PMID 22694265] Genetic Variations in MicroRNA Processing Genes Are Associated with Susceptibility in Depression

[PMID 19047128] Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

[PMID 19138993] Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.

[PMID 20211803] Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing gene...

Fluvoxamine chemical

Synonyms: Desiflu|Floxyfral|Fluvoxamin Stada|PMS Fluvoxamine|DU 23000|Faverin|Declimed Brand of Fluvoxamine Maleate|Fluvoxamin beta|neuraxpharm Brand of Fluvoxamine Maleate|Ratiopharm Brand of Fluvoxamine Maleate|Nu Pharm Brand of Fluvoxamine Maleate|Luvox|Nu-Pharm Brand of Fluvoxamine Maleate|1-Pentanone, 5-methoxy-1-(4-(trifluoromethyl)phenyl)-, O-(2-aminoethyl)oxime, (E)-|Fluvoxamine-CR|Fluvoxaminum|Fluvoxamina Geminis|Novo-Fluvoxamine|PMS-Fluvoxamine|Fluvoxamine Maleate, (E)-Isomer|Solvay Brand of Fluvoxamine Maleate|Fluvoxamin-ratiopharm|DU-23000|Fluvoxamin ratiopharm|Stadapharm Brand of Fluvoxa...
Definition: A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.

Biotin chemical

Synonyms: medobiotin|Medea Brand of Biotin Sodium Salt|Ziethen Brand of Biotin|D-(+)-biotin|BTN|Strathmann Brand of Biotin|Biotin [usan:inn:jan]|Vitamin B7|1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-|D-biotin|5-(2-Oxohexahydro-1H-thieno[3,4-D]imidazol-4-yl)pentanoate|D-Biotin factor S|Biotin Medopharm Brand|(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valeric acid|Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid|Biotin Forte|(3AS,4S,6ar)-hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valeric acid|Ritatin|(+)-cis-Hexahydro-2-oxo-1H-th...

A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Present in many foods; particularly rich sources include yeast, eggs, liver, certain fish (e.g. mackerel, salmon, sardines), soybeans, cauliflower and cow peas. Dietary supplement. Isol. from various higher plant sources, e.g. sweet corn seedlings and radish leaves Biotin D(+) is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes:; Biotin binds very tightly to the tetra...

Calcium Gluconate chemical

Synonyms: Glucobiogen|Calcipot|Gluconate de calcium|Coophavet Brand of Calcium Gluconate|Kalpren|Gluconic acid, calcium salt (2:1), D-|Ebucin|3M Brand of Calcium Gluconate Monohydrate|Calciofon|Calglucol|CBG|D-Gluconic acid, calcium salt (2:1)|Chaix et du Marais Brand of Calcium Gluconate|Pharmtech Brand of Calcium Gluconate|Calcium bis(d-gluconate)|Calcium gluconate, USAN|Calcium d-gluconate|Merial Brand of Calcium Gluconate|Gluconic acid, calcium salt, d-|Flopak Plain|Calcipur|Calglucon|Calcium D-gluconate (1:2)|Calcium Braun|Braun Brand of Calcium Gluconate|Calcium hexagluconate|Calcicol|Gluconate...

The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states. Food additive: firming agent, sequestrant, stabiliser, texturiser. Anticaking agent in powdered coffee Calcium gluconate is a mineral supplement. It is the form of calcium most widely used in the treatment of hypocalcemia. Calcium gluconate contains 9.3% calcium. It is also used to counteract an overdose of magnesium sulfate, often administered to pregnant women experiencing premature labor to slow or stop contractions. Excess magnesium sulfate can cause ...

phenylacetic acid chemical

Synonyms: sodium phenylacetate|2-Phenylethanoic acid|Benzylformic acid|Phenylethanoate|phenylacetic acid, sodium salt , carboxy-(11)C-labeled cpd|Phenylethanoic acid|Benzeneacetic acid|phenylacetic acid, lithium salt|phenylacetic acid, cesium salt|α-toluate|Benzylcarboxylic acid|a-Toluic acid|phenylacetic acid, rubidium salt|2-Phenylacetic acid|Benzeneacetic acid, 9CI|Benzylformate|Benzeneacetate|phenylacetic acid, sodium salt|Omega-Phenylacetic acid|2-Phenylacetate|a-Toluate|alpha-Toluate|w-Phenylacetate|omega-Phenylacetic acid|Phenylacetate|alpha-Toluic acid|phenylacetate|FEMA 2878|Omega-Phenylacet...
Definition: Found in essential oils, e.g. neroli, rose oil, free and as esters. Also present in grapes, raspberry, strawberry, cherimoya, other fruits, cheddar cheese, Swiss cheese, wine, black tea, peated malt and other foodstuffs. Flavouring ingredient Phenyl acetate (or phenylacetate) is a carboxylic acid ester that has been found in the biofluids of patients with nephritis and/or hepatitis as well as patients with phenylketonuria (PKU). Excess phenylalanine in the body can be disposed of through a transamination process leading to the production of phenylpyruvate. The phenylpyruvate can be further...

phenethylamine chemical

Synonyms: 2-Phenethylamine|(2-Aminoethyl)polystyrene|Benzeneethanamine, hydrochloride|phenethylamine mesylate|phenethylamine hydrochloride|1-Phenyl-2-aminoethane|Ethylamine, 2-phenyl-|β-phenylaethylamin (german)|Polystyrene A-NH2;|2-Phenylethylamine hydrochloride|β-aminoethylbenzene|Phenethylamine, β|Beta-phenethylamine|Beta-aminoethylbenzene|Phenethylamine|Omega-phenylethylamine|FEMA 3220|.omega.-phenylethylamine|2-phenyl-Ethanamine|Phenethylamine, beta|phenethylamine tosylate|Phenethylamine, hydrochloride|Benzeneethanamine, 9CI|phenethylamine sulfate|β-phenylethylamine|Phenethyl...
Definition: Present in cooked cabbage, cheeses, sherry, wine, processed lean fish, cocoa, raw cauliflower, raw beetroot and raw radish. Flavouring ingredient D-Phenylalanine increases the brain content of phenylethylamine. Phenylethylamine has been shown at least indirectly to satisfy the four main criteria required to demonstrate that a neuroamine sustains mood and that its deficit can be responsible for depression. Antidepressant drug therapy is an indirect (pharmacological) 'replacement' of brain phenylethylamine. Phenethylamine is an aromatic amine, which is a colorless liquid at room temperature. ...

5-methyltetrahydrofolate chemical

Synonyms: N5-Methyl-tetrahydrofolate|5-methyltetrahydropteroylglutamate|5-methyltetrahydrofolate, (L-Glu)-(S)-isomer|N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-Glutamic acid|5-methyltetrahydrofolate, calcium salt (1:1), (L-Glu)-isomer|mefolinate|[(6S)-5-methyl-5,6,7,8-tetrahydropteroyl]glutamate|N5-Methyl-tetrahydrofolic acid|Methyl folate|CH3-FH4|5-methyltetrahydrofolate, (DL-Glu)-isomer|5-methyltetrahydrofolate, methyl-(14)C-labeled, (L-Glu)-isomer|5-methyl-tetrahydrofolate|N5-methyltetrahydrofolate|N( 5)-Methyltetrahydrofolate|5-Methyltetrahydrofolate...
Definition: 5 methyltetrahydrofolic acid (5-MTHF) is the most biologically active form of the B-vitamin folic acid, also known generically as folate. 5-MTHF functions, in concert with vitamin B12, as a methyl-group donor involved in the conversion of the amino acid homocysteine to methionine. Methyl (CH3) group donation is vital to many bodily processes, including serotonin, melatonin, and DNA synthesis. Therapeutically, 5-MTHF is instrumental in reducing homocysteine levels, preventing neural tube defects, and improving vascular endothelial function. Research on folate supplementation suggests it play...