Summary of VEGFA

VEGFA encodes a protein that is a growth factor and is active in blood vessel formation and endothelial cell growth. It also induces endothelial cell proliferation, promotes cell migration, and inhibits cell death (R). 

Mutations are associated with higher risk for diabetes (R). 

The Function of VEGFA

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.

Protein names

Recommended name:

Vascular endothelial growth factor A

Short name:


Alternative name(s):

Vascular permeability factor

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Top Gene-Substance Interactions

VEGFA Interacts with These Diseases

Substances That Increase VEGFA

Substances That Decrease VEGFA

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity