Summary of USF1

USF1 is a transcription factor, which affects the expression of other genes. In particular, USF1 affects the production of proteins involved in keeping energy levels stable [R].

The effects of USF1 are complex - decreased levels may protect against cardiovascular disease, but may also increase the chance of cancer (see below for more information) USF1 SNPs are associated with heart disease in females [R],  increased triglycerides, and familial combined hyperlipidemia (FCHL) [R]. 

The Function of USF1

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

Protein names

Recommended name:

Upstream stimulatory factor 1

Alternative name(s):

Class B basic helix-loop-helix protein 11
Major late transcription factor 1

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Top Gene-Substance Interactions

USF1 Interacts with These Diseases

Substances That Increase USF1

Substances That Decrease USF1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity