Summary of UCP2

UCP2 is found primarily in the muscle [R]. UCP2 plays a role in nonshivering heat creation by the body, reducing the risk of obesity [R] and diabetes [R]. UCP2 regulates insulin secretion [R].

The Function of UCP2

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Protein names

Recommended name:

Mitochondrial uncoupling protein 2

Short name:


Alternative name(s):

Solute carrier family 25 member 8

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Top Gene-Substance Interactions

UCP2 Interacts with These Diseases


Substances That Increase UCP2

Substances That Decrease UCP2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity