• Navigation
  • Personalized Genetics Blog
  • Wellness Reports
  • About
  • Login
  • Analyze My Genes
  1. Home
  2. Genes
  3. TRPV1

TRPV1 (Transient receptor potential cation channel subfamily V member 1)

Loading...

The Function of TRPV1

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Transient receptor potential cation channel subfamily V member 1

Alternative name(s):

TrpV1
Capsaicin receptor
Osm-9-like TRP channel 1
OTRPC1
Vanilloid receptor 1

TRPV1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS222747 (TRPV1) ??
  2. RS222749 (TRPV1) ??
  3. RS224534 (TRPV1) ??
  4. RS8065080 (TRPV1) ??

Top Gene-Substance Interactions

TRPV1 Interacts with These Diseases

Disease Score

Substances That Increase TRPV1

Substances Interaction Organism Category

Substances That Decrease TRPV1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Sp1
  • PPAR-alpha

Tissue specificity:

Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Transmembrane transport of small molecules

Enzyme Regulation:

Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity). The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca(2+) and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. Intracellular PIP2 inhibits desensitization. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation.

Molecular Function:

  • Transmembrane Signaling Receptor Activity
  • Extracellular Ligand-Gated Ion Channel Activity
  • Excitatory Extracellular Ligand-Gated Ion Channel Activity
  • Calcium Channel Activity
  • Atp Binding
  • Calcium-Release Channel Activity
  • Chloride Channel Regulator Activity
  • Phosphatidylinositol Binding
  • Metal Ion Binding
  • Phosphoprotein Binding
  • Temperature-Gated Ion Channel Activity

Biological Processes:

  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Fever Generation
  • Microglial Cell Activation
  • Diet Induced Thermogenesis
  • Peptide Secretion
  • Lipid Metabolic Process
  • Transport
  • Cell Surface Receptor Signaling Pathway
  • Chemosensory Behavior
  • Glutamate Secretion
  • Cellular Response To Heat
  • Positive Regulation Of Apoptotic Process
  • Response To Peptide Hormone
  • Positive Regulation Of Nitric Oxide Biosynthetic Process
  • Behavioral Response To Pain
  • Sensory Perception Of Mechanical Stimulus
  • Thermoception
  • Detection Of Temperature Stimulus Involved In Thermoception
  • Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
  • Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain
  • Protein Homotetramerization
  • Smooth Muscle Contraction Involved In Micturition
  • Positive Regulation Of Gastric Acid Secretion
  • Calcium Ion Transmembrane Transport
  • Cellular Response To Alkaloid
  • Cellular Response To Atp
  • Cellular Response To Tumor Necrosis Factor
  • Cellular Response To Acidic Ph
  • Cellular Response To Temperature Stimulus
  • Negative Regulation Of Establishment Of Blood-Brain Barrier
  • Response To Capsazepine
  • Calcium Ion Import Into Cell
  • Cellular Response To Nerve Growth Factor Stimulus

Drug Bank:

  • Icosapent
  • Aspartame
  • Capsaicin
  • Alpha-Linolenic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_02631| AS27_13478| AS28_08309| capsaicin receptor| cation channel| D623_10007201| deltaN-TRPV1| M959_13516| MDA_GLEAN10006389| N300_03544| N301_15411| N302_07734| N303_12440| N305_15154| N306_12076| N307_07323| N308_07052| N309_08034| N311_04093| N312_02059| N320_06111| N321_03108| N322_08724| N324_00896| N325_10771| N326_04611| N327_06323| N328_05290| N329_12822| N330_12008| N331_01356| N333_01003| N334_10832| N335_04285| N336_06315| N340_00676| N341_02696| osm-9-like TRP channel 1| OTRPC1| PAL_GLEAN10010072| PANDA_018294| transient receptor potential cation channel, subfamily V, member 1| transient receptor potential cation channel V1| transient receptor potential channel vanilloid subfamily member-1| transient receptor potential V1| transient receptor potential vanilloid 1| transient receptor potential vanilloid 1a| transient receptor potential vanilloid 1b| transient receptor potential vanilloid 1 supraoptic nucleus| transient receptor potential vanilloid type 1| TRPV1/2| TRPV1alpha| TRPV1beta| TRPV1_SON| UY3_05042| vanilloid receptor 1| vanilloid receptor-like protein| vanilloid receptor subtype 1| vanilloid receptor type 1 like protein 1| vanilloid type 1 receptor| Vr1| VR-1| Vr1l1| VR.5'sv| Y1Q_028337| Y956_11577| trpv1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

Contact

  • Support

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • About Us
  • Login
  • Analyze My Genes
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2019 All Rights Reserved