Summary

TRIB3 causes insulin resistance. TRIB3 is induced by the transcription factor NF-kappaB. It disrupts insulin signaling by binding directly to Akt kinases and blocking their activation.


Function

Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.

Protein names

Recommended name:

Tribbles homolog 3

Short name:

SINK

Alternative name(s):

TRB-3
Neuronal cell death-inducible putative kinase
p65-interacting inhibitor of NF-kappa-B

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