The Function of TRAF1

Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

Protein names

Recommended name:

TNF receptor-associated factor 1

Alternative name(s):

Epstein-Barr virus-induced protein 6

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Top Gene-Substance Interactions

TRAF1 Interacts with These Diseases

Substances That Increase TRAF1

Substances That Decrease TRAF1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity