Summary of TNIP1

This gene encodes a protein that T plays a role in autoimmunity and tissue homeostasis. Mutations in this gene are associated with arthritis and lupus (R). 

The Function of TNIP1

Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Protein names

Recommended name:

TNFAIP3-interacting protein 1

Short name:


Alternative name(s):

A20-binding inhibitor of NF-kappa-B activation 1
HIV-1 Nef-interacting protein
Nef-associated factor 1
Virion-associated nuclear shuttling protein

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Top Gene-Substance Interactions

TNIP1 Interacts with These Diseases

Substances That Increase TNIP1

Substances That Decrease TNIP1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity