The Function of TNFSF10

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Protein names

Recommended name:

Tumor necrosis factor ligand superfamily member 10

Alternative name(s):

Apo-2 ligand
TNF-related apoptosis-inducing ligand
Protein TRAIL
CD antigen CD253

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Top Gene-Substance Interactions

TNFSF10 Interacts with These Diseases

Substances That Increase TNFSF10

Substances That Decrease TNFSF10

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity