The Function of TNFRSF1A

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

Protein names

Recommended name:

Tumor necrosis factor receptor superfamily member 1A

Alternative name(s):

Tumor necrosis factor receptor 1
TNF-R1
Tumor necrosis factor receptor type I
TNF-RI
TNFR-I
p55
p60
CD antigen CD120a
TBPI

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Top Gene-Substance Interactions

TNFRSF1A Interacts with These Diseases

Substances That Increase TNFRSF1A

Substances That Decrease TNFRSF1A

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical