Summary of TGFB1

TGF-beta plays an important role in autoimmune diseases, food intolerances, cancer, cognitive function, wound healing and other diseases.

TGF-b is a cytokine that affects the growth and proliferation of many cell types, and it has pro- and anti-inflammatory effects. Summary of Activities of TGF-beta:

  • Causes collateral damage in infections
  • Causes the growth/changes in tissue
  • Decreased acetylcholine
  • Decreased slow wave or deep sleep
  • Decreases muscle regeneration
  • Decreases the action of the vitamin D receptor
  • Increases free radicals
  • Can decrease bone density
  • It inhibits proliferation of most other cell types
  • Suppresses red blood cell formation and lymphocytes (T and B cells)
  • Suppresses antibody production
  • Suppresses Cytotoxic T Cell (CD8) and Natural Killer cell activity...this can cause viral infections to get out of control.
  • Deactivates macrophages
  • Promotes oral tolerance
  • Suppresses inflammation
  • Promotes wound healing and new blood vessel formation (angiogenesis)
  • Induces local inflammation and fibrosis
  • Stimulates extracellular matrix deposition
  • Promotes switch to IgA
  • Can increase cancer growth
  • Cause negative changes in the airways
  • Can benefit cognitive function (when very mildly elevated)

The Function of TGFB1

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292).

Protein names

Recommended name:

Transforming growth factor beta-1

Short name:

LAP

Alternative name(s):

TGF-beta-1

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Top Gene-Substance Interactions

TGFB1 Interacts with These Diseases

Fixes

Substances That Increase TGFB1

Substances That Decrease TGFB1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical