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  1. Home
  2. Genes
  3. TCN1

TCN1 (Transcobalamin 1)

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Summary of TCN1

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.

It's better to have this gene increased most of the time.
0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Transcobalamin-1

Short name:

HC

Alternative name(s):

TC-1
Haptocorrin
Protein R
Transcobalamin I
TC I
TCI

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TCN1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS34324219 (TCN1) ??
  2. RS526934 (TCN1) ??

Top Gene-Substance Interactions

TCN1 Interacts with These Diseases

Disease Score

Substances That Increase TCN1

Substances Interaction Organism Category

Substances That Decrease TCN1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • CUTL1
  • TGIF
  • Brachyury

Tissue specificity:

Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.

Gene Pathways:

  • Metabolism
  • Disease

Molecular Function:

  • Cobalamin Binding

Biological Processes:

  • Cobalt Ion Transport
  • Cobalamin Metabolic Process
  • Cobalamin Transport

Drug Bank:

  • Cyanocobalamin
  • Hydroxocobalamin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

TC-1| TC1| EGK_06179| GW7_04897| haptocorin| haptocorrin| HC| MDA_GLEAN10004062| protein R| TCI| Transcobalamin-1| transcobalamin I (vitamin B12 binding protein, R binder family)| tcn1
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