Summary of TCF4

The TCF4 gene encodes a gene that attaches to specific regions of DNA and helps control the activity of many other genes. The TCF4 protein is a transcription factor and helps the maturation of cells to carry out specific functions and the self-destruction of cells (R). 

The Function of TCF4

Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.

Protein names

Recommended name:

Transcription factor 4

Short name:


Alternative name(s):

Class B basic helix-loop-helix protein 19
Immunoglobulin transcription factor 2
SL3-3 enhancer factor 2

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Top Gene-Substance Interactions

TCF4 Interacts with These Diseases

Substances That Increase TCF4

Substances That Decrease TCF4

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity