Function

Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. May be involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. May be required for centrosome migration to the apical cell surface during early ciliogenesis.

Protein names

Recommended name:

Nesprin-1

Alternative name(s):

Enaptin
Myocyte nuclear envelope protein 1
Myne-1
Nuclear envelope spectrin repeat protein 1
Synaptic nuclear envelope protein 1
Syne-1

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Top Gene-Substance Interactions

SYNE1 Interacts with These Diseases

Substances That Increase SYNE1

Substances That Decrease SYNE1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical