Summary of STAT4

The STAT4 gene provides encodes a protein that acts as a transcription factor. The STAT4 protein is activated by cytokines, which are part of the inflammatory response to fight infection. It tells  immune cells to get rid of foreign invaders in the cell (R).

Mutations of this gene can cause arthritis, lupus, and other autoimmune disorders (R).


It's better to have this gene decreased most of the time.
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The Function of STAT4

Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

Protein names

Recommended name:

Signal transducer and activator of transcription 4

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Top Gene-Substance Interactions

STAT4 Interacts with These Diseases

Substances That Increase STAT4

Substances That Decrease STAT4

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical