Summary of STAT3

STAT3 is a protein that binds to DNA and increases expression of certain immune genes that can cause inflammation that leads to autoimmunity, but also fight infections. The STAT3 pathway is used by a variety of cytokines, hormones and growth factors to increase blood cell formation, immune cell development, stem cell maintenance, and growth. However, chronic activation of STAT3 underlies various diseases or disorders, such as cancer or obesity (R).

Read: Natural STAT3 Inhibitors

The STAT3 gene is part of a family known as the STAT genes. These genes provide instructions for making proteins that are part of essential chemical signaling pathways within cells. When STAT proteins are activated by certain chemical signals, they move into the nucleus and attach (bind) to specific areas of DNA. By binding to regulatory regions near genes, STAT proteins can regulate whether these genes are turned on or off. STAT proteins are called transcription factors on the basis of this action. The STAT3 protein is involved in many cellular functions. It regulates genes that are involved in cell growth and division, cell movement, and the self-destruction of cells (apoptosis). The STAT3 protein is active in tissues throughout the body. It plays an important role in the development and function of several body systems and is essential for life. In the immune system, the STAT3 protein transmits signals for the maturation of immune system cells, especially T cells and B cells. These cells help control the body's response to foreign invaders such as bacteria and fungi. In addition, the protein is involved in the regulation of inflammation, which is one way the immune system responds to infection or injury. In the skeletal system, the STAT3 protein is involved in the formation of specialized cells that build and break down bone tissue. These cells are necessary for the normal development and maintenance of bones.

STAT3 (Good):

  • helps with insulin sensitivity (R).
  • when chronically elevated will cause obesity (R).
  • suppresses of glucose production (R).
  • helps with liver regeneration (R).
  • helps reduce fatty liver disease (R).
  • has some anti-cancer properties, especially for CML (R).
  • helps clear pathogens (R).
  • suppresses IgE responses (R).

STAT3 (Bad):

  • STAT3 contributes to the development of IBD (R).
  • can help cause multiple sclerosis (MS)(R).
  • creates Th1 and Th17 cells (R), which are immune cells involved in autoimmunity.
  • produces pro-cancer products such as MMP-3, MMP-9, VEGF, HIF-1a, COX2, IL-6, IL-23 and ICAM1 (R).

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Protein names

Recommended name:

Signal transducer and activator of transcription 3

Alternative name(s):

Acute-phase response factor

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Top Gene-Substance Interactions

STAT3 Interacts with These Diseases

Fixes

Substances That Increase STAT3

Substances That Decrease STAT3

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical