The Function of SREBF1

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').

Protein names

Recommended name:

Sterol regulatory element-binding protein 1

Alternative name(s):

Class D basic helix-loop-helix protein 1
Sterol regulatory element-binding transcription factor 1

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Top Gene-Substance Interactions

SREBF1 Interacts with These Diseases

Substances That Increase SREBF1

Substances That Decrease SREBF1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity