The Function of SPI1
Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.
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Protein names
Recommended name:
Transcription factor PU.1Alternative name(s):
31 kDa-transforming proteinTop Gene-Substance Interactions
Substances That Increase SPI1
| Substances | Interaction | Organism | Category |
Substances That Decrease SPI1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Highly expressed in both FV-P and FV-A-induced erythro-leukemia cell lines that have undergone rearrangements of the SPI1 gene due to the insertion of SFFV. Negatively regulated by microRNA-155 (miR-155).
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
- Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
- Core Promoter Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Rna Polymerase Ii Transcription Factor Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Rna Binding
- Nfat Protein Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Lymphoid Progenitor Cell Differentiation
- Lymphocyte Differentiation
- Erythrocyte Differentiation
- Macrophage Differentiation
- Granulocyte Differentiation
- Somatic Stem Cell Population Maintenance
- Myeloid Dendritic Cell Differentiation
- Histone H3 Acetylation
- Hypermethylation Of Cpg Island
- Negative Regulation Of Mhc Class Ii Biosynthetic Process
- Regulation Of Erythrocyte Differentiation
- Negative Regulation Of Gene Expression, Epigenetic
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Anatomical Structure Regression
- Cellular Response To Ethanol
- Negative Regulation Of Histone H4 Acetylation
- Apoptotic Process Involved In Blood Vessel Morphogenesis
- Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter