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SPI1 (Spi-1 proto-oncogene)

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The Function of SPI1

Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.

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Protein names

Recommended name:

Transcription factor PU.1

Alternative name(s):

31 kDa-transforming protein

Top Gene-Substance Interactions

Substances That Increase SPI1

Substances Interaction Organism Category

Substances That Decrease SPI1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPalpha
  • AML1a
  • GATA-2
  • GATA-3
  • GATA-1
  • STAT3
  • IRF-2
  • c-Myb
  • Ik-1

Gene Pathways:

  • Acute myeloid leukemia
  • Pathways in cancer
  • Osteoclast differentiation

Induction:

Highly expressed in both FV-P and FV-A-induced erythro-leukemia cell lines that have undergone rearrangements of the SPI1 gene due to the insertion of SFFV. Negatively regulated by microRNA-155 (miR-155).

Molecular Function:

  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
  • Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Activity, Sequence-Specific Dna Binding
  • Core Promoter Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Rna Polymerase Ii Transcription Factor Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Rna Binding
  • Nfat Protein Binding

Biological Processes:

  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Lymphoid Progenitor Cell Differentiation
  • Lymphocyte Differentiation
  • Erythrocyte Differentiation
  • Macrophage Differentiation
  • Granulocyte Differentiation
  • Somatic Stem Cell Population Maintenance
  • Myeloid Dendritic Cell Differentiation
  • Histone H3 Acetylation
  • Hypermethylation Of Cpg Island
  • Negative Regulation Of Mhc Class Ii Biosynthetic Process
  • Regulation Of Erythrocyte Differentiation
  • Negative Regulation Of Gene Expression, Epigenetic
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Anatomical Structure Regression
  • Cellular Response To Ethanol
  • Negative Regulation Of Histone H4 Acetylation
  • Apoptotic Process Involved In Blood Vessel Morphogenesis
  • Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| OF| trypsin inhibitor| transcription factor| Myosin-binding protein C, cardiac-type| spleen focus forming virus (SFFV) proviral integration oncogene| 31 kDa transforming protein| 31 kDa-transforming protein| Anapl_16225| AS27_02266| AS28_01296| cocoon shell-associated trypsin inhibitor| CSTI| D623_10025524| Dis1| Dis-1| EH28_15066| hematopoietic transcription factor PU.1| Kazal-type serine proteinase inhibitor 1| MDA_GLEAN10019072| N300_12573| N301_00970| N302_01553| N303_08171| N306_08025| N307_01625| N308_14695| N309_11796| N310_09285| N311_11263| N312_12755| N320_00786| N321_03704| N322_07901| N324_06547| N325_08960| N327_13025| N328_03027| N329_10309| N331_03631| N332_14768| N333_12420| N334_09316| N336_12459| N339_08565| N340_02156| PAL_GLEAN10018137| PANDA_010596| pu1| Pu.1| SFFV proviral integration 1| SFFV proviral integration 1 protein| Sfpi-1| SFPI1| SPI-1| SPI1 ETS transcription factor| SPI1/PU.1| Spi-1/PU.1 transcription factor| spi-a| spleen focus forming virus proviral integration oncogene spi1| spleen focus forming virus (SFFV) proviral integration oncogene spi1| Tcfpu1| Tfpu.1| transcription factor PU.1| transcription factor PU.1 pseudogene| TREES_T100014290| UY3_01800| Y956_16679| Z169_07954| spi1

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