Summary of SOD2

Superoxide dismutases are enzymes that transform the superoxide (O2ˆ’) radical into either ordinary oxygen (O2) or hydrogen peroxide (H2O2). Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage.

SOD plays a protective role against oxidative stress, ionizing radiation, and inflammatory cytokines. SOD2 is found in the mitochondria, to combat the free radicals made there. SOD2 (also called MnSOD) transforms superoxide produced by your mitochondria into the less toxic hydrogen peroxide and oxygen.

This function allows SOD2 to clear mitochondrial reactive oxygen species (ROS) and confer protection against cell death. Superoxide has a few very positive functions in the body: clearing infections, cellular communication, creating new mitochondria and destroying tumors.

However, superoxide is really damaging and pretty much every chronic disease has too much oxidative stress as a contributory cause.


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The Function of SOD2

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Protein names

Recommended name:

Superoxide dismutase [Mn], mitochondrial

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Top Gene-Substance Interactions

SOD2 Interacts with These Diseases

Fixes

Substances That Increase SOD2

Substances That Decrease SOD2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical