The Function of SLC7A5

Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.

Protein names

Recommended name:

Large neutral amino acids transporter small subunit 1

Short name:


Alternative name(s):

4F2 light chain
4F2 LC
CD98 light chain
Integral membrane protein E16
L-type amino acid transporter 1
Solute carrier family 7 member 5
y+ system cationic amino acid transporter

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Top Gene-Substance Interactions

SLC7A5 Interacts with These Diseases

Substances That Increase SLC7A5

Substances That Decrease SLC7A5

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity