Summary of SLC47A1

The gene codes for a protein, solute carrier family 47 member 1. It is found on the Smith-Magenis syndrome region on chromosome 17. The protein has an unknown function [R].


The Function of SLC47A1

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.

Protein names

Recommended name:

Multidrug and toxin extrusion protein 1

Short name:

MATE-1

Alternative name(s):

hMATE-1
Solute carrier family 47 member 1

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Top Gene-Substance Interactions

SLC47A1 Interacts with These Diseases

Substances That Increase SLC47A1

Substances That Decrease SLC47A1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical