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  1. Home
  2. Genes
  3. SLC23A1

SLC23A1 (Solute carrier family 23 member 1)

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Summary of SLC23A1

The gene codes for a protein, solute carrier family 23 member 1. It is one of the two transporters that aids with the absorption of vitamin C into the body and the distribution of it to the organs require two sodium-dependent vitamin C transporters [R].

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The Function of SLC23A1

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.

Protein names

Recommended name:

Solute carrier family 23 member 1

Alternative name(s):

Na(+
Sodium-dependent vitamin C transporter 1
hSVCT1
Yolk sac permease-like molecule 3

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SLC23A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10063949 (SLC23A1) ??
  2. RS11950646 (SLC23A1) ??
  3. RS33972313 (SLC23A1) ??

Top Gene-Substance Interactions

SLC23A1 Interacts with These Diseases

Disease Score

Substances That Increase SLC23A1

Substances Interaction Organism Category

Substances That Decrease SLC23A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NCX/Ncx
  • Nkx3-1
  • Nkx3-1 v1
  • C/EBPalpha
  • E47

Tissue specificity:

Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.

Gene Pathways:

  • Vitamin digestion and absorption
  • Metabolism
  • Disease

Molecular Function:

  • L-Ascorbate:Sodium Symporter Activity
  • Sodium Ion Transmembrane Transporter Activity
  • Nucleobase Transmembrane Transporter Activity
  • L-Ascorbic Acid Transporter Activity
  • Dehydroascorbic Acid Transporter Activity
  • Sodium-Dependent L-Ascorbate Transmembrane Transporter Activity

Biological Processes:

  • Nucleobase-Containing Compound Metabolic Process
  • Sodium Ion Transport
  • Brain Development
  • Response To Toxic Substance
  • Nucleobase Transport
  • L-Ascorbic Acid Transport
  • L-Ascorbic Acid Metabolic Process
  • Lung Development
  • Dehydroascorbic Acid Transport
  • Transepithelial L-Ascorbic Acid Transport

Drug Bank:

  • Vitamin C
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SLC23A2| solute carrier family 23 (nucleobase transporters), member 2| A306_14690| AS27_09540| D18Ucla2| D623_10027804| H920_19251| hSVCT1| I79_014960| M91_15312| M959_06941| Marginal zone B- and B1-cell-specific protein| MDA_GLEAN10012462| N300_15925| N302_13646| N303_10658| N307_06391| N309_01157| Na(+)/L-ascorbic acid transporter 1| sodium-coupled ascorbic acid transporter 1| sodium-dependent vitamin C transporter 1| sodium-dependent vitamin C transporter-1| solute carrier family 23 (ascorbic acid transporter), member 1| solute carrier family 23 , member 1| solute carrier family 23 member 1-like protein| solute carrier family 23 (nucleobase transporters), member 1| SVCT1| TREES_T100019639| UY3_06473| Y1Q_030780| Y956_14157| yolk sac permease-like molecule 3| YSPL3| slc23a1
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