Summary of SLC23A1
The gene codes for a protein, solute carrier family 23 member 1. It is one of the two transporters that aids with the absorption of vitamin C into the body and the distribution of it to the organs require two sodium-dependent vitamin C transporters [R].
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The Function of SLC23A1
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
Protein names
Recommended name:
Solute carrier family 23 member 1Alternative name(s):
Na(+Sodium-dependent vitamin C transporter 1
hSVCT1
Yolk sac permease-like molecule 3
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- RS10063949 (SLC23A1) ??
- RS11950646 (SLC23A1) ??
- RS33972313 (SLC23A1) ??
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Top Gene-Substance Interactions
SLC23A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase SLC23A1
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC23A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.
Gene Pathways:
Molecular Function:
- L-Ascorbate:Sodium Symporter Activity
- Sodium Ion Transmembrane Transporter Activity
- Nucleobase Transmembrane Transporter Activity
- L-Ascorbic Acid Transporter Activity
- Dehydroascorbic Acid Transporter Activity
- Sodium-Dependent L-Ascorbate Transmembrane Transporter Activity
Biological Processes:
- Nucleobase-Containing Compound Metabolic Process
- Sodium Ion Transport
- Brain Development
- Response To Toxic Substance
- Nucleobase Transport
- L-Ascorbic Acid Transport
- L-Ascorbic Acid Metabolic Process
- Lung Development
- Dehydroascorbic Acid Transport
- Transepithelial L-Ascorbic Acid Transport
Drug Bank:
- Vitamin C