Summary of SLC22A4

The gene codes for a protein, solute carrier family 22 member 4. Transport is ATP-dependent [R].

The Function of SLC22A4

Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).

Protein names

Recommended name:

Solute carrier family 22 member 4

Alternative name(s):

Ergothioneine transporter
ET transporter
Organic cation/carnitine transporter 1

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Top Gene-Substance Interactions

SLC22A4 Interacts with These Diseases

Substances That Increase SLC22A4

Substances That Decrease SLC22A4

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity