Summary of SLC22A3
The gene codes for a protein, solute carrier family 22 member 3. It is important for eliminating many drugs and environmental toxins [R].
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The Function of SLC22A3
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
Protein names
Recommended name:
Solute carrier family 22 member 3Short name:
EMTAlternative name(s):
Extraneuronal monoamine transporterOrganic cation transporter 3
- RS10755578 (SLC22A3) ??
- RS149565105 (SLC22A3) ??
- RS2048327 (SLC22A3) ??
- RS2481044 (SLC22A3) ??
- RS2504916 (SLC22A3) ??
- RS3120139 (SLC22A3) ??
- RS3127599 (SLC22A3) ??
- RS402219 (SLC22A3) ??
- RS7758229 (SLC22A3) ??
- RS7767084 (SLC22A3) ??
- RS9351730 (SLC22A3) ??
- RS9364554 (SLC22A3) ??
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Top Gene-Substance Interactions
SLC22A3 Interacts with These Diseases
| Disease | Score |
Substances That Increase SLC22A3
| Substances | Interaction | Organism | Category |
Substances That Decrease SLC22A3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.
Gene Pathways:
Molecular Function:
- Dopamine Transmembrane Transporter Activity
- Organic Cation Transmembrane Transporter Activity
- Quaternary Ammonium Group Transmembrane Transporter Activity
- Toxin Transporter Activity
Biological Processes:
- Drug Transmembrane Transport
- Organic Cation Transport
- Quaternary Ammonium Group Transport
- Dopamine Transport
- Regulation Of Appetite
- Histamine Uptake
- Ammonium Transmembrane Transport
- Mitophagy In Response To Mitochondrial Depolarization
Drug Bank:
- Amphetamine
- Choline
- Cimetidine
- Clonidine
- Colchicine
- Dopamine
- Estradiol
- Guanidine
- Histamine Phosphate
- Irinotecan
- Lamivudine
- Melphalan
- Metformin
- Norepinephrine
- Oxaliplatin
- Phenoxybenzamine
- Prazosin
- Procainamide
- Testosterone
- Vincristine
- Nicotine
- Adefovir Dipivoxil
- Desipramine
- Imipramine
- Methamphetamine
- Progesterone