Summary

The gene codes for a protein, solute carrier family 1 member 2. Mutations which increase or decrease expression of the protein are linked to amyotrophic lateral sclerosis [R].


Function

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Protein names

Recommended name:

Excitatory amino acid transporter 2

Alternative name(s):

Glutamate/aspartate transporter II
Sodium-dependent glutamate/aspartate transporter 2
Solute carrier family 1 member 2

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