Summary of SIRT1

SIRT enzymes œturn off certain genes that promote aging, such as those involved in inflammation, in fat synthesis and storage, and in blood sugar management. (R)

When proteins are undergoing stress, SIRT1 adds acetyl groups to proteins as a response to changes induced by inflammation and oxidation.

Sirtuins (like SIRT1) remove these acetyl groups to keep the protein in service longer than usual. SIRT1 powerfully helps metabolic issues that cause diabesity.

SIRT1 also make you more sensitive to Thyroid hormones (R) and  more sensitive to vitamin D (R, R2).

SIRT1 inhibits pathways involved in aging (IGF-1 (RmTOR (R).)

SIRT1 protects you from oxidative stress.

 

SIRT1 regulates the strength (amplitude) and the duration of your natural biological rhythms.

A reduction in SIRT 1 and SIRT 3 enzymes lead to (R):

  • Neurodegeneration in the brain,
  • Vascular inflammation, producing damage to blood vessels that can result in stroke or heart attack,
  • Increased fat storage in the liver, which can lead to fatty liver disease (NAFLD),
  • Increased fat production and deposition in white adipose tissue, the primary fat storage form found in dangerous belly fat,
  • Insulin resistance, preventing cells from appropriately removing glucose from blood, producing higher blood sugar levels and leading directly to metabolic syndrome,
  • Fatigue, loss of muscle strength, and fatty infiltration of muscles, resulting in reduced fatty acid oxidation (œburning), thereby depriving muscles of their normal sources of energy.

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The Function of SIRT1

SirtT1 75 kDa fragment: catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly.

Protein names

Recommended name:

NAD-dependent protein deacetylase sirtuin-1

Alternative name(s):

hSIRT1
Regulatory protein SIR2 homolog 1
SIR2-like protein 1
hSIR2
75SirT1

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Top Gene-Substance Interactions

SIRT1 Interacts with These Diseases

Fixes

Substances That Increase SIRT1

Substances That Decrease SIRT1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical