The Function of SET

Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.

Protein names

Recommended name:

Protein SET

Short name:

IGAAD

Alternative name(s):

HLA-DR-associated protein II
Inhibitor of granzyme A-activated DNase
PHAPII
Phosphatase 2A inhibitor I2PP2A
I-2PP2A
Template-activating factor I
TAF-I

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Top Gene-Substance Interactions

SET Interacts with These Diseases

Substances That Increase SET

Substances That Decrease SET

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical