Summary of SERPINA3

The gene codes for a protein, serpin family A member 3. Variations are linked to Alzheimer's disease, and deficiency may cause liver disease. Mutations are associated with Parkinson disease and chronic obstructive pulmonary disease [R].


Function

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.

Protein names

Recommended name:

Alpha-1-antichymotrypsin

Short name:

ACT

Alternative name(s):

Cell growth-inhibiting gene 24/25 protein
Serpin A3

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Top Gene-Substance Interactions

SERPINA3 Interacts with These Diseases

Substances That Increase SERPINA3

Substances That Decrease SERPINA3

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical