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SERINC3 (Serine incorporator 3)

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The Function of SERINC3

Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).

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Protein names

Recommended name:

Serine incorporator 3

Alternative name(s):

Tumor differentially expressed protein 1

Top Gene-Substance Interactions

SERINC3 Interacts with These Diseases

Disease Score

Substances That Increase SERINC3

Substances Interaction Organism Category

Substances That Decrease SERINC3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • AhR
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.

Molecular Function:

  • L-Serine Transmembrane Transporter Activity

Biological Processes:

  • Phosphatidylserine Metabolic Process
  • Sphingolipid Metabolic Process
  • Detection Of Virus
  • Innate Immune Response
  • Defense Response To Virus
  • Positive Regulation Of Endoplasmic Reticulum Stress-Induced Intrinsic Apoptotic Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_02228| aigp1| AIGP-1| AS27_02483| AS28_06917| axotomy-induced glyco/Golgi protein 1| axotomy-induced glycoprotein 1| CB1_002228014| DIFF33| EGK_02384| GW7_20396| H920_08366| I79_011659| M91_07792| M959_06593| MDA_GLEAN10017221| membrane protein TMS-1| N300_15774| N301_06933| N302_00224| N303_14099| N305_03162| N306_01641| N307_07027| N308_10704| N309_01215| N310_11362| N311_00367| N312_06592| N320_09978| N321_13992| N322_06545| N324_07032| N325_11331| N327_08943| N328_00511| N329_11366| N330_10411| N332_00130| N333_03322| N334_00681| N335_00385| N340_11999| N341_00136| PAL_GLEAN10024370| PANDA_005628| SBBI99| serine incorporator 1-like protein| serine incorporator 3-like protein| TDE| TDE1| tms1| tms-1| TREES_T100011889| tumor differentially expressed 1| Tumor differentially expressed protein 1| UY3_14174| Y1Q_029268| Y956_05645| Z169_04465| serinc3

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