The Function of SERINC3
Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).
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Protein names
Recommended name:
Serine incorporator 3Alternative name(s):
Tumor differentially expressed protein 1Top Gene-Substance Interactions
SERINC3 Interacts with These Diseases
| Disease | Score |
Substances That Increase SERINC3
| Substances | Interaction | Organism | Category |
Substances That Decrease SERINC3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.
Molecular Function:
Biological Processes:
- Phosphatidylserine Metabolic Process
- Sphingolipid Metabolic Process
- Detection Of Virus
- Innate Immune Response
- Defense Response To Virus
- Positive Regulation Of Endoplasmic Reticulum Stress-Induced Intrinsic Apoptotic Signaling Pathway