Summary of SELP

The gene codes for a protein, selectin P. It redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes [R].


The Function of SELP

Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Protein names

Recommended name:

Selenoprotein P

Alternative name(s):

SeP

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Top Gene-Substance Interactions

SELP Interacts with These Diseases

Substances That Increase SELP

Substances That Decrease SELP

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical