Summary of RXRA

The gene codes for a protein, retinoid X receptor alpha. The protein is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators [R].


The Function of RXRA

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

Protein names

Recommended name:

Retinoic acid receptor RXR-alpha

Alternative name(s):

Nuclear receptor subfamily 2 group B member 1
Retinoid X receptor alpha

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Top Gene-Substance Interactions

RXRA Interacts with These Diseases

Substances That Increase RXRA

Substances That Decrease RXRA

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical