Summary of ROBO1

The gene codes for a protein, roundabout guidance receptor 1. SLIT-family proteins activate the receptor which results in a repulsive effect on glioma cell guidance in the developing brain. A related gene is on chromosome 3 [R].

The Function of ROBO1

Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development.

Protein names

Recommended name:

Roundabout homolog 1

Alternative name(s):

Deleted in U twenty twenty

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Top Gene-Substance Interactions

ROBO1 Interacts with These Diseases

Substances That Increase ROBO1

Substances That Decrease ROBO1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity