Summary of RLIM

The gene codes for a protein, ring finger protein, LIM domain interacting. The protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor [R].


The Function of RLIM

E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.

Protein names

Recommended name:

E3 ubiquitin-protein ligase RLIM

Short name:

R-LIM

Alternative name(s):

LIM domain-interacting RING finger protein
RING finger LIM domain-binding protein
RING finger protein 12
Renal carcinoma antigen NY-REN-43

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Top Gene-Substance Interactions

RLIM Interacts with These Diseases

Substances That Increase RLIM

Substances That Decrease RLIM

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical