Summary of RGS2

The gene codes for a protein, regulator of G-protein signaling 2. The protein mediates myeloid differentiation and may play a role in leukemogenesis [R].


The Function of RGS2

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).

Protein names

Recommended name:

Regulator of G-protein signaling 2

Short name:

RGS2

Alternative name(s):

Cell growth-inhibiting gene 31 protein
G0/G1 switch regulatory protein 8

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Top Gene-Substance Interactions

RGS2 Interacts with These Diseases

Substances That Increase RGS2

Substances That Decrease RGS2

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical