The Function of PTPRC

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.

Protein names

Recommended name:

Receptor-type tyrosine-protein phosphatase C

Short name:


Alternative name(s):

Leukocyte common antigen
CD antigen CD45

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Top Gene-Substance Interactions

PTPRC Interacts with These Diseases

Substances That Increase PTPRC

Substances That Decrease PTPRC

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity