Summary of PTPN1

PTPN1 codes PTP1B, which in higher levels is related to:

  • diabetes/blood sugar,
  • cardiovascular disease, 
  • rheumatoid arthritis,
  • immune function,
  • fat storage/obesity,
  • cancer

The Function of PTPN1

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Protein names

Recommended name:

Tyrosine-protein phosphatase non-receptor type 1

Short name:


Alternative name(s):

Protein-tyrosine phosphatase 1B

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Top Gene-Substance Interactions

PTPN1 Interacts with These Diseases

Substances That Increase PTPN1

Substances That Decrease PTPN1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity