The Function of PTHLH
Osteostatin is a potent inhibitor of osteoclastic bone resorption.
Protein names
Recommended name:
Parathyroid hormone-related proteinShort name:
PLPAlternative name(s):
PTH-rPPTHrP
Parathyroid hormone-like protein
PTHrP[107-139]
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- RS10771399 (PTHLH) ??
- RS12371778 (PTHLH) ??
- RS258401 (PTHLH) ??
- RS258415 (PTHLH) ??
- RS4420311 (PTHLH) ??
- RS7953528 (PTHLH) ??
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Top Gene-Substance Interactions
PTHLH Interacts with These Diseases
| Disease | Score |
Substances That Increase PTHLH
| Substances | Interaction | Organism | Category |
Substances That Decrease PTHLH
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression (R):
Tissue specificity:
Ubiquitous. Also expressed in the mammary gland.
Gene Pathways:
Molecular Function:
Biological Processes:
- Skeletal System Development
- Osteoblast Development
- Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
- Cell-Cell Signaling
- Female Pregnancy
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Epidermis Development
- Regulation Of Gene Expression
- Positive Regulation Of Camp Biosynthetic Process
- Negative Regulation Of Chondrocyte Differentiation
- Camp Metabolic Process