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PTH (Parathyroid hormone)

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The Function of PTH

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

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Protein names

Recommended name:

Parathyroid hormone

Short name:

PTH

Alternative name(s):

Parathormone
Parathyrin

PTH SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6254 (PTH) ??
  2. RS6256 (PTH) ??
  3. RS7927727 (PTH) ??
  4. RS9630182 (PTH) ??

Top Gene-Substance Interactions

PTH Interacts with These Diseases

Disease Score

Substances That Increase PTH

Substances Interaction Organism Category

Substances That Decrease PTH

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Hypoparathyroidism familial isolatedFrom UniProt: Hypoparathyroidism, familial isolated (FIH): A disorder characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone . Clinical features include seizures, tetany and cramps. [MIM:146200]

     From NCBI Gene: This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] From UniProt: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • E4BP4
  • c-Fos
  • IRF-1
  • C/EBPbeta
  • AP-1
  • c-Jun
  • MEF-2A

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Signal Transduction

Molecular Function:

  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Hormone Activity
  • Parathyroid Hormone Receptor Binding
  • Peptide Hormone Receptor Binding

Biological Processes:

  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Skeletal System Development
  • Cellular Calcium Ion Homeostasis
  • G-Protein Coupled Receptor Signaling Pathway
  • Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
  • Rho Protein Signal Transduction
  • Cell-Cell Signaling
  • Hormone-Mediated Apoptotic Signaling Pathway
  • Positive Regulation Of Signal Transduction
  • Response To Lead Ion
  • Regulation Of Gene Expression
  • Positive Regulation Of Bone Mineralization
  • Positive Regulation Of Camp Biosynthetic Process
  • Response To Vitamin D
  • Cellular Macromolecule Biosynthetic Process
  • Bone Resorption
  • Response To Ethanol
  • Positive Regulation Of Glycogen Biosynthetic Process
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Camp Metabolic Process
  • Positive Regulation Of Glucose Import
  • Response To Cadmium Ion
  • Homeostasis Of Number Of Cells Within A Tissue
  • Response To Parathyroid Hormone
  • Response To Fibroblast Growth Factor
  • Positive Regulation Of Cell Proliferation In Bone Marrow
  • Negative Regulation Of Apoptotic Process In Bone Marrow
  • Positive Regulation Of Osteoclast Proliferation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_14539| AS28_03664| GW7_05480| hypothalamic parathyroid hormone| I79_016734| M959_03155| N300_06568| N301_04319| N302_07580| N303_05641| N305_13152| N306_00226| N307_07911| N308_00687| N309_01115| N310_12197| N311_04768| N312_00766| N320_10849| N321_13103| N322_02301| N324_11066| N325_08859| N326_11463| N327_00205| N328_03250| N329_10209| N330_03283| N332_01095| N333_11815| N334_01876| N336_12802| N340_03841| N341_02891| PANDA_015778| parathormone| parathyrin| parathyroid hormone 1| Parathyroid hormone containing protein| Peptidyl-tRNA hydrolase| preproparathyroid hormone| prepro-PTH| protein yippee-like 1| PTH1| PTH-(1-84)| Pthp| Pthr1| thyroid hormone| TREES_T100011594| UY3_05986| Y1Q_028010| Y956_04559| pth

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