Summary of PTGS2

This gene encodes a key enzyme in prostaglandin biosynthesis. It is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis (R). 


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Function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Protein names

Recommended name:

Prostaglandin G/H synthase 2

Short name:

COX-2

Alternative name(s):

Cyclooxygenase-2
PHS II
Prostaglandin H2 synthase 2
PGH synthase 2
PGHS-2
Prostaglandin-endoperoxide synthase 2

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Top Gene-Substance Interactions

PTGS2 Interacts with These Diseases

Substances That Increase PTGS2

Substances That Decrease PTGS2

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical