The Function of PRKCE
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.
Protein names
Recommended name:
Protein kinase C epsilon typeAlternative name(s):
nPKC-epsilonGet a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS
- RS10168349 (PRKCE) ??
- RS10495928 (PRKCE) ??
- RS12373805 (PRKCE) ??
- RS12622534 (PRKCE) ??
- RS12712969 (PRKCE) ??
- RS13008603 (PRKCE) ??
- RS13396424 (PRKCE) ??
- RS140838333 (PRKCE) ??
- RS281508 (PRKCE) ??
- RS4953318 (PRKCE) ??
- RS6751349 (PRKCE) ??
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Top Gene-Substance Interactions
PRKCE Interacts with These Diseases
Disease | Score |
Substances That Increase PRKCE
Substances | Interaction | Organism | Category |
Substances That Decrease PRKCE
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression (R):
Gene Pathways:
Enzyme Regulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation.
Molecular Function:
- Actin Monomer Binding
- Protein Serine/Threonine Kinase Activity
- Protein Kinase C Activity
- Calcium-Independent Protein Kinase C Activity
- Signal Transducer Activity
- Atp Binding
- Enzyme Activator Activity
- Enzyme Binding
- Receptor Activator Activity
- Ethanol Binding
- Metal Ion Binding
Biological Processes:
- Macrophage Activation Involved In Immune Response
- Protein Phosphorylation
- Apoptotic Process
- Cell Cycle
- Cell Adhesion
- Signal Transduction
- Activation Of Phospholipase C Activity
- Positive Regulation Of Epithelial Cell Migration
- Positive Regulation Of Fibroblast Migration
- Positive Regulation Of Cell-Substrate Adhesion
- Peptidyl-Serine Phosphorylation
- Platelet Activation
- Positive Regulation Of Actin Filament Polymerization
- Negative Regulation Of Protein Ubiquitination
- Lipopolysaccharide-Mediated Signaling Pathway
- Positive Regulation Of Insulin Secretion
- Positive Regulation Of Synaptic Transmission, Gabaergic
- Positive Regulation Of Cytokinesis
- Intracellular Signal Transduction
- Locomotory Exploration Behavior
- Tram-Dependent Toll-Like Receptor 4 Signaling Pathway
- Fc-Gamma Receptor Signaling Pathway Involved In Phagocytosis
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Response To Morphine
- Positive Regulation Of Mapk Cascade
- Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of Lipid Catabolic Process
- Release Of Sequestered Calcium Ion Into Cytosol
- Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
- Cell Division
- Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
- Positive Regulation Of Mucus Secretion
- Cellular Response To Ethanol
- Cellular Response To Prostaglandin E Stimulus
- Cellular Response To Hypoxia
- Positive Regulation Of Wound Healing
- Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
- Positive Regulation Of Cellular Glucuronidation