Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.
- RS10168349 (PRKCE) ??
- RS10495928 (PRKCE) ??
- RS12373805 (PRKCE) ??
- RS12622534 (PRKCE) ??
- RS12712969 (PRKCE) ??
- RS13008603 (PRKCE) ??
- RS13396424 (PRKCE) ??
- RS140838333 (PRKCE) ??
- RS281508 (PRKCE) ??
- RS4953318 (PRKCE) ??
- RS6751349 (PRKCE) ??
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Top Gene-Substance Interactions
Gene Interacts with Diseases
|Disease||Inference Score||References/Inference chemicals|
All Ways to Increase Gene
|Isoproterenol||Increases expression||Rats (R)||Drug, Popular drugs, Substances of Biological Interest, Synthetic Toxin|
|Phenylephrine||Increases localization||Mice (R)||Consumable Natural Treatments, Substances of Biological Interest|
|Capsaicin||Increases abundance, Increases activity , Increases reaction||Humans (R) , Humans (R) , Humans (R)||Consumable Natural Treatments, Substances of Biological Interest, Plant Toxin, Beneficial Substances, Important Natural Compounds|
|Oxygen||Increases activity||Mice (R)||Consumable Natural Treatments, Substances of Biological Interest|
|Progesterone||Increases reaction, Increases secretion||Cows (R) , Cows (R)||Consumable Natural Treatments, Popular drugs, Substances of Biological Interest, Beneficial Substances, Important Natural Compounds|
|Dinoprost||Increases reaction, Increases secretion||Cows (R) , Cows (R)||Consumable Natural Treatments, Substances of Biological Interest, Important Natural Compounds|
|Streptozocin||Increases expression||Rats (R)||Drug, Substances of Biological Interest, Synthetic Toxin|
|Acetylcysteine||Increases activity, Increases localization||Rats (R) , Rats (R)||Consumable Natural Treatments, Popular drugs, Substances of Biological Interest, Beneficial Substances, Important Natural Compounds|
|Reactive Oxygen Species||Increases abundance, Increases activity||Humans (R) , Humans (R)||Substances of Biological Interest, Important Natural Compounds|
|Buthionine Sulfoximine||Increases activity, Increases expression||Rats (R) , Rats (R)||Substances of Biological Interest|
All Ways to Decrease Gene
|Isoproterenol||Decreases reaction||Rats (R)||Drug, Popular drugs, Substances of Biological Interest, Synthetic Toxin|
|Phenylephrine||Decreases reaction||Mice (R)||Consumable Natural Treatments, Substances of Biological Interest|
|Pt(O,O'-acac)(gamma-acac)(DMS)||Decreases reaction||Humans (R)||Substances of Biological Interest|
|Oxygen||Decreases reaction||Mice (R)||Consumable Natural Treatments, Substances of Biological Interest|
|Streptozocin||Decreases reaction||Rats (R)||Drug, Substances of Biological Interest, Synthetic Toxin|
|Cobaltous chloride||Decreases expression||Humans (R)||Substances of Biological Interest, Toxins|
|Progesterone||Decreases reaction||Cows (R)||Consumable Natural Treatments, Popular drugs, Substances of Biological Interest, Beneficial Substances, Important Natural Compounds|
|Ethanol||Decreases reaction||Rats (R)||Consumable Natural Treatments, Drug, Substances of Biological Interest, Airborne Pollutant, Food Toxin, Household Toxin, Industrial/Workplace Toxin, Natural Toxin, Pollutant, Synthetic Toxin, Beneficial Substances, Important Natural Compounds|
|CPU0213||Decreases reaction||Rats (R)||Substances of Biological Interest|
|Berberine||Decreases activity||Rats (R)||Consumable Natural Treatments, Substances of Biological Interest, Beneficial Substances, Important Natural Compounds|
Conditions with Increased Gene Activity
|Condition||Change (log2fold)||Comparison||Species||Experimental variables||Experiment name|
Conditions with Decreased Gene Activity
|Condition||Change (log2fold)||Comparison||Species||Experimental variables||Experiment name|
The following transcription factors increase gene production (R):
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation.
- Actin Monomer Binding
- Atp Binding
- Calcium-Independent Protein Kinase C Activity
- Enzyme Activator Activity
- Enzyme Binding
- Ethanol Binding
- Metal Ion Binding
- Protein Kinase C Activity
- Protein Serine/Threonine Kinase Activity
- Receptor Activator Activity
- Signal Transducer Activity
- Activation Of Phospholipase C Activity
- Apoptotic Process
- Cell Adhesion
- Cell Cycle
- Cell Division
- Cellular Response To Ethanol
- Cellular Response To Hypoxia
- Cellular Response To Prostaglandin E Stimulus
- Fc-Gamma Receptor Signaling Pathway Involved In Phagocytosis
- Intracellular Signal Transduction
- Lipopolysaccharide-Mediated Signaling Pathway
- Locomotory Exploration Behavior
- Macrophage Activation Involved In Immune Response
- Negative Regulation Of Protein Ubiquitination
- Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
- Peptidyl-Serine Phosphorylation
- Platelet Activation
- Positive Regulation Of Actin Filament Polymerization
- Positive Regulation Of Cell-Substrate Adhesion
- Positive Regulation Of Cellular Glucuronidation
- Positive Regulation Of Cytokinesis
- Positive Regulation Of Epithelial Cell Migration
- Positive Regulation Of Fibroblast Migration
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Insulin Secretion
- Positive Regulation Of Lipid Catabolic Process
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Mucus Secretion
- Positive Regulation Of Synaptic Transmission, Gabaergic
- Positive Regulation Of Wound Healing
- Protein Phosphorylation
- Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
- Regulation Of Peptidyl-Tyrosine Phosphorylation
- Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
- Release Of Sequestered Calcium Ion Into Cytosol
- Response To Morphine
- Signal Transduction
- Tram-Dependent Toll-Like Receptor 4 Signaling Pathway