Summary of PPARG

The Good

PPAR gamma:

  • decreases blood glucose. (R)
  • are generally anti-inflammatory,
  • help mice can live longer (and maybe people). (R)
  • Leads to increased energy expenditure, fat utilization, and excretion. (R)
  • decreases inflammation in your heart and reduces cholesterol. (R)
  • reduces blood pressure (R).
  • decreases heart disease.  (R)
  • combats diseases such as Multiple sclerosis and Alzheimer (R).
  • can help IBD (Crohn's, colitis). (R)

The Bad

PPAR gamma:

  • can cause weight gain in some ways (R),
  • is not good for bone density.  They increase bone destroying cells (osteoclasts) and decrease bone-producing cells (osteoblasts).
  • increases sebum, which can leads to acne. (R)

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The Function of PPARG

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.

Protein names

Recommended name:

Peroxisome proliferator-activated receptor gamma

Alternative name(s):

Nuclear receptor subfamily 1 group C member 3

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Top Gene-Substance Interactions

PPARG Interacts with These Diseases


Substances That Increase PPARG

Substances That Decrease PPARG

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity