Summary

The Good

PPAR gamma:

  • decreases blood glucose. (R)
  • are generally anti-inflammatory,
  • help mice can live longer (and maybe people). (R)
  • Leads to increased energy expenditure, fat utilization, and excretion. (R)
  • decreases inflammation in your heart and reduces cholesterol. (R)
  • reduces blood pressure (R).
  • decreases heart disease.  (R)
  • combats diseases such as Multiple sclerosis and Alzheimer (R).
  • can help IBD (Crohn's, colitis). (R)

The Bad

PPAR gamma:

  • can cause weight gain in some ways (R),
  • is not good for bone density.  They increase bone destroying cells (osteoclasts) and decrease bone-producing cells (osteoblasts).
  • increases sebum, which can leads to acne. (R)

It's better to have this gene increased most of the time.

Function

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.

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