Summary of PPARA

PPAR alpha is a very important protein for metabolizing fat and glucose, which helps with weight loss. It alters the expression of a large number of genes. It's important for energy production. 

Mice lacking PPAR-alpha have an impaired response to fasting, including low levels of ketone bodies, hypoglycemia, and fatty liver. PPAR-alpha increases bile synthesis/secretion (R).

PPAR alpha inhibits inflammation and animal models of autoimmune conditions such as Multiple Sclerosis (R). PPAR-a can help increase IGF-1, which will help you build muscle (R).

PPAR-alpha is a protein (transcription factor) that increases fat breakdown in the liver and elsewhere.  Good metabolism is important for energy production.

PPAR-alpha alters the expression of a large number of genes. PPAR-alpha is activated under conditions of calorie restriction and is necessary for the process of ketogenesis, a key adaptive response to prolonged fasting.

PPAR-alpha is mainly found in the liver and brown fat, followed by the heart and kidney. Lower PPAR-alpha expression levels are found in the small and large intestine, muscle and adrenal gland.

Activation of PPAR-alpha promotes uptake, utilization, and breakdown of fatty acids by increasing genes involved in fatty acid transport, binding, activation, and oxidation.

Mice lacking PPAR-alpha have an impaired response to fasting, characterized by major metabolic disturbances including low levels of ketone bodies, hypoglycemia, and fatty liver. PPAR-alpha is at the core of fat utilization, as well glucose production and bile synthesis/secretion (R).

PPAR alpha inhibits animal models of autoimmune conditions such as MS (R). PPAR alpha is protective against heart disease by inhibiting macrophage inflammation and increasing cholesterol efflux (via LXR and ABCA1) (R).

Read: About PPAR Alpha and Natural Ways To Activate It.


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Protein names

Recommended name:

Peroxisome proliferator-activated receptor alpha

Alternative name(s):

PPAR-alpha
Nuclear receptor subfamily 1 group C member 1

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Top Gene-Substance Interactions

PPARA Interacts with These Diseases

Fixes

Substances That Increase PPARA

Substances That Decrease PPARA

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical