Summary of PON1

PON1 is responsible for detoxifying organophosphate pesticides, nerve gasses and various drugs (R). PON1 has a role in healthy ageing (R) and helps protect against bacterial infection (R), heart disease (R), stroke, diabetes, liver and kidney diseases, arthritis, eye diseases (macular degeneration), cancer and HIV infection (R). People with Autism have lower PON1 activity (arylesterase activity) (R).  

The Function of PON1

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

Protein names

Recommended name:

Serum paraoxonase/arylesterase 1

Short name:


Alternative name(s):

Aromatic esterase 1
A-esterase 1
Serum aryldialkylphosphatase 1

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Top Gene-Substance Interactions

PON1 Interacts with These Diseases


Substances That Increase PON1

Substances That Decrease PON1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity