Summary of POMC

POMC (proopiomelanocortin) makes a protein that is cut into peptides that have different functions in the body (R). 

Adrenocorticotropic hormone (ACTH) is produced from the POMC protein and it helps maintain blood sugar levels, protects the body from stress, and stops inflammation (R).

Other peptides formed from POMC include: β-MSH peptide, which plays a role in weight regulation; α-MSH peptide, which helps maintain the correct energy balance; γ-MSH, which is involved in regulating the amount of sodium in the body and controlling blood pressure; and β-endorphin, which stimulates signaling for pain relief (R).


Function

Beta-endorphin and Met-enkephalin are endogenous opiates.

Protein names

Recommended name:

Pro-opiomelanocortin

Short name:

POMC

Alternative name(s):

Corticotropin-lipotropin
Gamma-MSH
Adrenocorticotropic hormone
ACTH
Alpha-MSH
CLIP
Beta-LPH
Gamma-LPH
Beta-MSH

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Top Gene-Substance Interactions

POMC Interacts with These Diseases

Substances That Increase POMC

Substances That Decrease POMC

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical