The Function of PMEPA1

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).

Protein names

Recommended name:

Protein TMEPAI

Alternative name(s):

Prostate transmembrane protein androgen induced 1
Solid tumor-associated 1 protein
Transmembrane prostate androgen-induced protein

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Top Gene-Substance Interactions

PMEPA1 Interacts with These Diseases

Substances That Increase PMEPA1

Substances That Decrease PMEPA1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity