Summary of PLIN1

The Perilipin 1 (PLIN1) gene belongs to the family of genes called Perilipins. A product of this gene is a major constituent of fat-cell tissues. The protein encoded by this gene has a pivotal role to play in fat metabolism. Perilipin is an important regulator of fat storage. It's useful for preventing insulin resistance, but can also cause weight gain (R).

The Function of PLIN1

Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.

Protein names

Recommended name:


Alternative name(s):

Lipid droplet-associated protein

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Top Gene-Substance Interactions

PLIN1 Interacts with These Diseases


Substances That Increase PLIN1

Substances That Decrease PLIN1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity