The Function of PAX6

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

Protein names

Recommended name:

Paired box protein Pax-6

Alternative name(s):

Aniridia type II protein

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Top Gene-Substance Interactions

PAX6 Interacts with These Diseases

Substances That Increase PAX6

Substances That Decrease PAX6

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity