Summary of PADI4

This gene encodes a protein that plays a role in granulocyte and macrophage development for inflammation and immune response (R). 


The Function of PADI4

Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.

Protein names

Recommended name:

Protein-arginine deiminase type-4

Short name:

HL-60 PAD

Alternative name(s):

Peptidylarginine deiminase IV
Protein-arginine deiminase type IV

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Top Gene-Substance Interactions

PADI4 Interacts with These Diseases

Substances That Increase PADI4

Substances That Decrease PADI4

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical